Dr. Evan Snyder

Name: Dr. Evan Y. Snyder M.D., PhD

Position Title: Professor

Education:

Institution	Degree (if applicable)	Year(s)	Field of Study
University of Pennsylvania, Philadelphia, PA	B.A.	1973	Psychology
Oxford University (Balliol College), UK		1973-1974	Psychology
Linguistics Institute (Linguistics Society of America)		1974	Linguistics
University of Pennsylvania, Philadelphia, PA	MD, PhD	1980	Anatomy (Neuroscience)

Positions:

INTERNSHIPS/RESIDENCIES
1980-83	Pediatrics, Children's Hosp.-Boston
1983-84, 86-87	Pediatric Neurology, Harvard Longwood Neurology Training Program
1984-85	Chief Medical Resident, Children's Hosp.-Boston.
1987	Chief Neurology Resident, Children's Hosp.-Boston

FELLOWSHIPS & ACADEMIC
1985-86, 88-91	Clinical Fellow/Junior Attending in Medicine (Neonatology), Children's Hosp.-Boston
1985-92	Postdoctoral Research Fellow, Dept. of Genetics, Harvard Med School.
1992-95	Instructor in Neurology (Neonatology), Harvard Med. School.
1996-Present	Assistant Professor in Neurology, Harvard Med. School.
2003-Present	Professor & Director, Stem Cells & Regeneration Program, The Burnham Institute.

HOSPITAL APPOINTMENTS
1989-	Assistant in Medicine (Newborn Medicine), Children's Hospital, Boston, MA Neonatologist, Brigham & Women's Hospital, Boston, MA Pediatrician, Beth Israel Hospital, Boston, MA
1992-2001	Assistant in Neurology (Neuroscience), Children's Hospital, Boston, MA
1997-	Pediatrician, Beverly Hospital, Beverly, MA
1998-	Pediatrician, South Shore Hospital, South Weymouth, MA
1998-2001	Assistant in Neurosurgery (Neuroscience Research), Children's Hospital, Boston, MA
2001-	Assistant in Neurology (Neuroscience Research), Beth Israel-Deaconess Medical Center, Boston, MA

Board Certification: Pediatrics (1985); Child Neurology. (1992); Perinatal-Neonatal Medicine (1993)

Honors:


1973	Beta Kappa; Summa Cum Laude with Highest Honors/Distinction, U. Penn.; Netzky Scholar
1974	Linguistics Soc. of Amer. Scholar; Med. Scientist Training Prog. Awardee, NIH
1975	Jeffers Prize in Neurologic Research, U. Penn
1979	CIBA Found. Award; Bell Award for Outstanding Res., U. Penn.; Excellence of Res. Award, Eastern Res. Forum; Earle Award for Res., Tissue Culture Assoc. & W. Alton Jones Cell Sci. Ctr.; Korey Award for Research, Amer. Acad. of Neurol.
1980	Clark Prize for Research, U. Penn.; Sigma Xi Res. Honor Soc.
1984	Chief Resident, Dept. of Med., Children's Hosp.-Boston
1986	Chief Resident, Dept. of Neurol., Children's Hosp.-Boston
1988	Hearst Award For Res. into Neuromotor Disability, Harvard.
1988	Jeffers Prize in Neurologic Research, U. Penn
1988	Farley Fellowship Award for Res., Children's Hosp.-Boston; Clinical Investigator Develop. Award, NINDS
1989	Young Investigator Award, Child Neurol. Soc.; Young Investigator Award, Eastern Soc. for Pediatr. Res.
1991	New Program Awardee, Mental Retardation Research Core, NICHD.
1993	Nominee, HMS Teaching Award; Hearst Award For Res. into Neuromotor Disability, Harvard
1995	Elected Fellow of Amer. Soc. Neural Transplantation.
1997-99	Elected Councilor of Amer. Soc. Neural Transplantation
1998	Child Neurol. Soc. Visiting Scientist Awardee; State-of-Art Lecturer, Soc. Ped. Res.; State- of-Art Lecturer, Midwest Soc. Ped. Res.
1999	Tooley Visiting Lecturer, UCSF. Elected Nat'l Secr., Amer. Soc. Neural Transplant & Repair; FDR Awardee (March of Dimes); Curran Neonatal Lectureship, U. South Florida; Boss Chair of Research, Brain Tumor Soc; Pfizer Traveling Fellow
2000	Rudolph Visiting Prof., Baylor; Elliot Mem. Lecturer, New Eng. Conf. on Perinatal Research; Outstanding Speaker Award, Advances in Clin. Chem., Edu. & New Technology, Am. Assoc. Clin. Chem.
2001	Jacob's Ladder Found. Annual Prize & Lectureship in Neurodegen. Genetic Disease, Toronto Hosp. for Sick Children; Grass Lecturer in Neurosci., Univ. Louisville.
2002	New Program Awardee, Mental Retardation Research Core, NICHD.Keynote Speaker, Brain Tumor Soc; Keynote Speaker, Intern. MS Soc.
2002	Keynote Speaker, World Lysosomal Disease Conf.
2002	Ridgeway Visiting Scholar, Univ. Missouri-Columbia School of Medicine.

Selected Publications:


1.	Ryder EF, Snyder EY, Cepko CL, Establishment & characterization of multipotent neural cell lines, J Neurobiol 21:356-375 (1990).
2.	Turner DL, Snyder EY, Cepko CL, Cell lineage analysis in the embryonic mouse retina by retroviral vector-mediated gene transfer, Neuron 4: 833-845 (1990).
3.	Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartweig EA, Cepko CL, Multipotent neural cell lines can engraft & participate in development of mouse cerebellum, Cell 68: 33-51 (1992).
4.	Kitchen DL, Snyder EY, Gottlieb DI, FGF & EGF are mitogens for immortalized neural progenitors, J. Neurobiol. 25: 797-807 (1994). [*co-PIs]
5.	Snyder EY, Taylor RM, Wolfe JH, Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain, Nature 374: 367-370 (1995).
6.	Snyder EY, Flax JD, Transplantation of neural progenitors & stem-like cells as a strategy for gene therapy & repair of neurodegenerative diseases, Ment Retard Develop Disabil Res Rev 1: 27-38 (1995).
7.	Lacorazza HD, Flax JD, Snyder EY, Jendoubi M, Expression of human b-hexosaminidase a-subunit gene (the defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cells, Nature Med. 4: 424-429 (1996).
8.	Snyder EY, Macklis JD, Multipotent neural stem-like cells may be uniquely suited for therapy of some neurodegenerative conditions Clin Neurosci 3: 310-316, 1996.
9.	Snyder EY, Wolfe JH, CNS cell transplantation: a novel therapy for storage diseases, Curr Opin in Neurol 9: 126-136 (1996).
10.	Snyder EY, Fisher LJ, Gene therapy for neurologic diseases, Current Opin. in Pediatrics 8: 558-568 (1996).
11.	11. Lynch WP, Snyder EY, Qualtierre L, Portis JL, Sharpe AH, Neither neurovirulent retroviral envelope protein nor viral particles are sufficient for induction of acute spongiform neurodegeneration: evidence from engineered neural progenitor-derived chimeric mouse brains, J. Virol. 70: 8896-8907 (1996).
12.	12. Taylor RM, Snyder EY, Widespread engraftment of neural progenitor & stem-like cells throughout newborn mouse brain, Transplantation Proceedings 29: 845-847 (1997).
13.	Snyder EY, Senut M-C, Use of non-neuronal cells for gene delivery, Neurobiology of Disease 4: 69-102 (1997).
14.	Snyder EY, Yoon CH, Flax JD, Macklis JD, Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex PNAS 94: 11663-11668 (1997).
15.	Rosario CM, Yandava BD, Kosaras B, Zurakowski D, Sidman RL, Snyder EY, Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action Development 124: 4213-4224 (1997).
16.	Snyder EY, Neural stem cells: Developmental lessons with therapeutic potential, The Neuroscientist 4(6): 408-425 (1998).
17.	Flax JD, Aurora S, Yang C, Simonin C, Wills AM, Billinghurst L, Jendoubi M, Sidman RL, Wolfe JH, Kim SU, Snyder EY, Engraftable human neural stem cells respond to developmental cues, replace neurons, & express foreign genes Nature Biotech 16:1033-1039 (1998) [on cover].
18.	Billinghurst LL, Taylor RM, Snyder EY, Remyelination: Cellular & gene therapy, Sem. In Ped. Neurol 5: 211-228 (1998).
19.	Yandava BD, Billinghurst LL, Snyder EY, "Global cell replacement is feasible via neural stem cell transplantation: evidence from the shiverer dysmyelinated mouse brain PNAS 96: 7029-7034 (1999).
20.	Lynch WP, Sharpe AH, Snyder EY, Neural stem cells as engraftable packaging lines can optimize viral vector-mediated gene delivery to the CNS: evidence from studying retroviral env-related neurodegeneration, J Virol 73:6841-6851 (1999).
21.	Liu Y, Himes BT, Solowska J, Moul J, Chow SY, Park KI, Tessler A, Murray M, Snyder EY, Fischer I, Intraspinal delivery of NT-3 using neural stem cells genetically modified by recombinant retrovirus Exp Neurol 158:9-26 (1999).
22.	Vescovi AL, Snyder EY, Establishment & properties of neural stem cell clones: plasticity in vitro & in vivo, Brain Pathology 9: 569-598 (1999).
23.	Wagner J, Akerud P, Castro D, Holm PC, Snyder EY, Perlmann, Arenas E, Type 1 astrocytes induce a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells Nature Biotech. 17: 653-659 (1999) [on cover].
24.	Park KI, Liu S, Flax JD, Nissim S, Stieg PE, Snyder EY, Transplantation of neural stem-like cells: developmental insights may suggest new therapies for spinal cord & other CNS dysfunction, J Neurotrauma 16/8:675-687 (1999).
25.	Rubio FJ, Kokaia Z, del Arco A, Garcia-Simon MI, Snyder EY, Lindvall O, Satrustegui J, Martinez-Serrano A, BDNF gene transfer to the mammalian brain using CNS-derived neural precursorsGene Therapy 6: 1851-1866 (1999).
26.	Rowitch DH, St Jacques B, Lee SMK, Flax JD, Snyder EY, McMahon AP, Sonic hedgehog regulates proliferation & inhibits differentiation of CNS precursor cells, J. Neurosci. 19(20): 8954-8965 (1999).
27.	Ourednik V, Ourednik J, Park KI, Snyder EY, Neural stem cells: a versatile tool for cell replacement & gene therapy in the CNS, Clin Genet 46: 267-278 (1999).
28.	Villa A, Snyder EY, Vescovi A, Martinez-Serrano A, Establishment & properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS, Exp. Neurol. 161: 67-84 (2000) [*co-PIs].
29.	Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Black PMcL, Breakefield XO, Snyder EY, Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial tumors, PNAS USA 97: 12846-12851 (2000).
30.	Doering L, Snyder EY, Cholinergic expression by a neural stem cell line grafted to the adult medial septum/diagonal band complex. J Neurosci Res 61: 597-604 (2000).
31.	Akerud P, Canals JM, Snyder EY, Arenas E, Neuroprotection through delivery of GDNF by neural stem cells in a mouse model of Parkinson's Disease J Neurosci 21: 8108-8118 (2001).
32.	Himes BT, Liu Y, Solowska, JM, Snyder EY, Fischer I, Tessler A, Transplants of cells genetically modified to express NT-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats J Neurosci Res 65: 549-64. (2001).
33.	Ourednik V, Ourednik J, Flax JD, Zawada M, Hutt C, Yang CL, Park KI, Kim SU, Sidman RL, Freed CR, Snyder EY, Segregation of human neural stem cells in the developing primate forebrain Science 293: 1820-24 (2001).
34.	Park KI, Stieg PE, Snyder EY, Transplantation of neural stem cells: cellular & gene therapy in pediatric hypoxic-ischemic brain injury, in: Chan, P.H. (ed.) Cerebrovascular Disease, Cambridge University Press, pp. 299-316 (2001).
35.	Ourednik J, Ourednik V, Lynch WP, Schachner M, Snyder EY, Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons: evidence in aged mice Nature Biotech 20: 1103-70. (2002). [on cover]
36.	Teng YD, Lavik EB, Qu X, Ourednik J, Zurakowski D, Langer R, Snyder EY, Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells PNAS 99: 3024-3029 (2002).
37.	Zlomanczuk P, Mrugala M, de la Iglesia HO, Ourednik V, Quesenberry PJ, Snyder EY, Schwartz WJ. Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus, Exp Neurol 174: 162-168. (2002).
38.	Riess, P., Zhang, C., Saatman, K. E., Laurer, H. L., Longhi, L. G., Raghupathi, R., Lenzlinger, P. M., Lifshitz, J., Boockvar, J., Neugebauer, E., Snyder, E. Y., McIntosh, T. K. Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery 51: 1043-52; discussion 1052-4. (2002)
39.	Park KI, Ourednik J, Ourednik V, Taylor RM, Aboody KA, Auguste KI, Lachyankar M, Redmond DE, Snyder EY, Global Gene and Cell Replacement Strategies via Stem Cells, Gene Therapy 9: 613-624 (2002).
40.	Yang M, Stull ND, Berk MA, Snyder EY, Iacovitti L, Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopomine-lesioned rat Exp Neurol 177: 50-60 (2002).
41.	Park KI, Teng YD, Snyder EY, The injured brain interacts reciprocally with scaffolds seeded with neural stem cells to reconstitute lost tissue, Nature Biotech. 20: 111-117 (2002).
42.	Ourednik J, Ourednik V, Lachyankar M, Snyder EY, Neural tissue and stem cell grafts may induce regenerative plasticity in damaged mammalian brain, Clinical Neuroscience Research 2: 80-85 (2002).
43.	Park KI, Snyder EY, News & Views: Limitations in Brain Repair, Nature Med. 8: 928-30 (2002).
44.	Lu P, Jones LL, Snyder, EY, Tuszynski MH, Neural stem cells constitutively secrete neurotrophic factors and promote robust axonal grow after spinal cord injury. Exp. Neurol 181: 115-129 (2003).
45.	Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M., McIntosh T, O'Rourke DM, Koury S, Weissleder R, Black PMcL, Weiss W, Snyder EY, Neural stem cell biology may be well-suited for improving brain tumor therapies, The Cancer Journal 9: 189-204 (2003).
46.	Shah K, Tang Y, Messerli SM, Snyder E, Breakefield X, Weissleder R, In vivo tracking of neural progenitor cell migration to glioblastomas, Human Gene Therapy (in press).
47.	Boockvar JA, Kapitonov D, Kapoor G, Schouten J, Counelis GJ, Bogler O, Snyder EY, McIntosh TK, O'Rourke DM., Constitutive EGFR signaling confers a motile phenotype to neural stem cells Molec Cell Neurosci (in press).
48.	Kosaras B, Johnson KL, Khosrotehrani K, Escolar ML, Wenger DA, Sidman RL, Kurtzberg J, Bianchi DW, Snyder EY, Umbilical cord cells colonize the degenerating human brain but do not differentiate into neural cells (submitted, Nature).
49.	Park KI, Snyder EY, Developmental patterns constitutively shift to compensate for CNS insult (in revision, Nature)
50.	Zigova T, Snyder EY, Sanberg PR (eds) Therapeutic Uses of Neural Stem Cells, Humana Press (in press).