Who We Are
U.S. Stem Cell, Inc. (OTC:USRM) is an emerging leader in the worldwide development of proprietary, physician-based stem cell therapies and novel regenerative medicine solutions. Based in Sunrise, Florida, the Company has developed a clinical protocol and kit— AdipoCellTM —that helps isolate a patient’s own stem cells while keeping them intact, in order to harness their healing ability for a wide variety of indications.
USRM also trains and certifies physicians from around the world in the administration of stem cell therapies and protocols — to date, more than 700+ physicians worldwide. The company is also in the process of opening standalone and partnered stem cell clinics — to date, four in the United States—and several worldwide.
There are two targeted stem cell products. USRM currently has in development for the repair of cardiac tissue: MyoCellR and MyoCell SVF-1TM— both of which are poised to go to the next phase of clinical development.
MyoCellR, a muscle stem cell therapy intended to improve cardiac function after heart attack, involves utilizing USRM’s proprietary cell-culturing process to isolate and expand muscle stem cells (myoblasts) to assist in combating scar tissue in order to improve cardiac function. Phase I, II and part one of a phase II/III trial have been completed; Part two of a Phase II/III is approved by the FDA and ready to begin patient enrollment.
MyoCell SDF-1, a more robust form of MyoCellR, involves using the same myoblast cells as in MyoCellR with the addition of a gene-modified adenovirus vector in order to release additional stromal derived factor 1, or SDF-1 protein. By modifying the myoblasts to express SDF-1 prior to injection, the levels of SDF proteins in the heart can increase. In preclinical studies, MyoCell SDF-1 provided a 54% improvement of cardiac function compared to a 27% improvement in the original MyoCell composition while the animal placebo control group declined 10%. Preclinical trials also demonstrated MyoCell SDF-1 has the potential to enhance blood vessel formation in damaged hearts. The IND application was approved by the FDA.
USRM is currently seeking partners to fully develop and commercialize these products, which have already demonstrated safety and efficacy in preliminary studies.
U.S. Stem Cell also has two product lines that are derivatives of its core work in humans: veterinary stem cell products, which have demonstrated marketability in the high-end equine market; and stem cell banking, a service that is a secondary business unit that helps facilitate its core competency of stem cell therapies.
Dr. William P. Murphy, Jr., M.D.
Chairman of the Board
Dr. William P. Murphy, Jr., currently serves the Chairman of the Board of U.S. Stem Cell, having joined the as a member of the Board of Directors in June 2003. A highly successful entrepreneur and inventor, the owner of 17 patents, a distinguished speaker and published author, Dr. Murphy founded Small Parts, Inc., a supplier of high quality mechanical components for design engineers in 1964 and served as its Chairman until his retirement in April 2005. Small Parts, Inc. was later acquired by Amazon.com, Inc. in March 2005. From October 1999 until October 2004, Dr. Murphy served as the Chairman and Chief Executive Officer of Hyperion, Inc., a medical diagnosis company which filed for involuntary bankruptcy in December 2003.
Dr. Murphy is the founder of Cordis Corporation (now Cordis Johnson & Johnson) which he led as President, Chairman and Chief Executive Officer at various times during his 28 years at Cordis until his retirement in October 1985. Cordis Johnson & Johnson is a leading firm in cardiovascular instrumentation. Dr. Murphy received an M.D. in 1947 from the University of Illinois and a B.S in pre-medicine from Harvard College in 1946. He also studied physiologic instrumentation at Massachusetts Institute of Technology. Dr. Murphy is the recipient of a number of honors, including the prestigious Lemelson-MIT Lifetime Achievement Award, the MIT Corporate Leadership Award, the Distinguished Service Award from North American Society of Pacing and Electrophysiology and the Jay Malina Award from the Beacon Council, Miami-Dade County’s economic development arm.
Why U.S. Stem Cell?
We have treated over 4000 patients
We have trained over 600 practitioners
We have spent more than $125 million in research and development
We do not utilize harmful drugs to isolate cells from peripheral blood.
We have worked with several countries to help develop and write the regulations for stem cell therapy
Our protocols are being utilized in 6 continents
We are the inventors and developers of our own therapies
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Listing Title: Bioheart Inc