Stem Cell Transplant Center
The Stem Cell Transplant Center at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center is one of the largest and most experienced pediatric stem cell transplant programs in the world. Dana-Farber/Boston Children’s is an integrated pediatric oncology program through Dana-Farber Cancer Institute and Boston Children’s Hospital that provides — in one specialized program — all the services of both a leading cancer center and a pediatric hospital.
Pediatric stem cell transplantation, also called bone marrow transplantation, is used to treat many types of conditions affecting children and teens. While traditionally used to treat cancers and blood disorders, stem cell transplants are increasingly being used to treat a growing range of other conditions, including metabolic diseases, genetic immunodeficiencies, and other disorders. Learn about the conditions treated by stem cell transplant.
Our expertise in stem cell transplant
Dana Farber/Boston Children’s Cancer and Blood Disorders Center is a world leader in pediatric stem cell transplantation.
We perform more than 90 stem cell transplants each year for children and teens with many types of cancer and other disorders. Our pediatric stem cell transplantation team includes some of the world’s most experienced and knowledgeable pediatric stem cell transplant doctors and scientists, as well as nationally recognized pediatric specialists.
Our doctors work collaboratively with national research groups, including the Children’s Oncology Group, Blood and Marrow Transplant Clinical Trials Network and the Pediatric Blood and Marrow Transplant Consortium to develop innovative clinical trials and expand transplantation for new conditions.
We have an active stem cell research program which includes scientists who partner with our clinical care team to improve outcomes for hematopoietic stem cell transplantation.
Our approach to stem cell transplant
More in-depth information about our Stem Cell Transplant Center is available on the Dana-Farber/Boston Children’s Cancer and Blood Disorders website. Learn about:
Our state-of-the-art stem cell transplant facilities
What to expect during a stem cell transplant
Our stem cell transplant team
Conditions treated through stem cell transplant
Stem cell transplant clinical trials
About the Stem Cell Transplantation Program
The Stem Cell Transplantation program at Dana-Farber/Brigham and Women’s Cancer Center is one of the largest and most experienced stem cell transplant programs in the world. Since our program began in 1972, we have performed more than 8,700 transplants for the treatment of blood cancers and related disorders.Our Program’s center-specific outcomes have been recognized as among the best in the United States. The Program’s team of experts is highly regarded in the field of hematopoietic stem cell transplants, and will work to address your needs throughout treatment and beyond.
Our doctors, researchers, and patient care staff will collaborate with our hematologic malignancies care teams and your referring physician to create the most effective treatment strategies. These experienced and dedicated stem cell transplant specialists will follow you through the continuum of transplant services in both the inpatient and outpatient settings.
Our stem cell transplant services include:
Autologous transplant, using your own stem cells.
Allogeneic transplant, using stem cells from a family member, unrelated matching donor, or umbilical cord blood.
Comprehensive services for related and unrelated donors.
Access to our extensive offering of specialized stem cell transplant clinical trials.
Transplantation for adults over age 60.
What is a stem cell transplant?
Stem cell transplantation refers to a procedure where healthy stem cells are transplanted from one individual to another, or using an individual’s own stem cells. Sources of stem cells include bone marrow, peripheral blood or umbilical cord blood. You may hear the procedure referred to as a bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) or umbilical cord blood transplantation (UCBT), depending on the source of the cells that are transplanted.
Hematopoietic stem cells can grow into any of the cells found within the bloodstream. They make blood cells and the components that your immune system needs to function. During a transplant, your body is infused with healthy stem cells which then grow and produce all of the different parts of the blood that both your body and your immune system need.
When is a stem cell transplant needed?
You may need a stem cell transplant when:
Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed.
Your bone marrow or blood cells have become diseased and need to be replaced.
You have a disease that is treated with high doses of chemotherapy and/or radiation treatment, which destroys both cancerous and stem cells at the same time.
What happens in a stem cell transplant?
When you undergo a stem cell transplant, doctors replace your stem cells with healthy new stem cells from a volunteer stem cell donor. Here’s a brief overview of what happens:
You will receive chemotherapy and/or radiation to kill the diseased cells. This treatment, known as conditioning, will damage and possibly destroy your bone marrow/blood stem cells.
You will receive new, healthy stem cells (in a process called an infusion, which is similar to a blood transfusion) to replace the destroyed cells. Unlike other forms of organ transplant (e.g. heart, kidney, etc.) surgery is not required for a stem cell transplant.
The transplanted cells will begin to grow and produce healthy red and white blood cells and platelets.
The process of growing new blood cells generally takes between two and four weeks; during this time you may be hospitalized so that doctors can monitor your progress.
In some cases, your own stem cells may be suitable for the procedure; this is called an autologous transplant. If you need stem cells from a donor (an allogeneic transplant) we will help coordinate that process through our comprehensive donor services program. Your physician will decide what type of transplant should be used for your treatment and the source of the transplanted stem cells.
Our accreditations and credentials
Charter member of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) of the National Institutes of Health (NIH)
Member of the Center for International Blood and Marrow Transplant Research (CIBMTR)
Member of the Alliance for Clinical Trials in Oncology (formerly CALGB)
Fully accredited with the National Marrow Donor Program (NMDP)
Accredited by the Foundation for the Accreditation of Cellular Therapy (FACT)
The Harvard Department of Stem Cell and Regenerative Biology (HSCRB) is committed to advancing biomedical research for the benefit of humankind, and to delivering innovative teaching and training at the interface of biology and medicine.
Our dynamic, collegial department is part of Harvard’s Faculty of Arts and Sciences and Harvard Medical School. This reflects the strategic importance of our work across the university and opens up unrivaled opportunities for meaningful collaboration.
The ultimate goal of HSCRB’s research, whether it is focused on the most basic level of cellular development or on screening chemical compounds for potential drugs, is combating disease and tissue degeneration and improving human health. Research is conducted in our state-of-the-art new laboratories in Cambridge, and in one of Harvard’s affiliated world-class hospitals.
HSCRB is the academic home of 20 faculty and over 350 stem cell scientists conducting research on Harvard’s Cambridge and Longwood campuses as well as Massachusetts General Hospital, Children’s Hospital Boston, Dana Farber Cancer Institute, Brigham & Women’s Hospital, and the Broad Institute. Over 200 HSCRB scientists conduct work in the Bauer-Fairchild laboratories in Cambridge.
HSCRB administrators are dedicated to achieving the Department’s goals in research and education. We support faculty in their roles as scientists, teachers, and University leaders. We support students’ efforts to learn and grow through coursework, lab experiences, and advising. We help each other in labs and offices throughout the Department and University to create a productive, supportive, and collegial work environment.
Please stop by the Administrative Suite in the Bauer Laboratory Building so we can introduce ourselves.
To pursue the promise of stem cell science and regenerative medicine, in 2004 Harvard founded the Harvard Stem Cell Institute (HSCI), a novel network of stem cell scientists that extends from the University to its affiliated hospitals and the biomedical industry. Leveraging its unique environment, HSCI has helped to change the paradigm for biomedical research and education by enabling cross-institutional and cross-disciplinary collaboration and student participation in cutting-edge science.
The Harvard community and the greater Boston area is home to the largest concentration of biomedical researchers in the world, which allows HSCI to advance stem cell biology and translational medicine in a way no other single entity can. Stem cell biologists across all the departments, schools, institutes, and affiliated hospitals of Harvard are able to collaborate on a daily basis with scientist-physicians, chemists, bioengineers, and experts in business, law, and ethics in order to develop tomorrow’s treatments and cures today.
HSCI is focused on bringing stem cell-based treatments to patients as quickly as possible. While continuing to advance scientific discovery, we are developing treatments for diseases of aging, the blood, cancer, metabolism, and neurological disorders. To accomplish this, we bring together more than 1,000 scientists in the schools and affiliated hospitals of Harvard, fund novel research, and implement new collaborative academic and industrial models.
HSCI is funded entirely by private philanthropy and supports discounted rates for its members at several core facilities in the Harvard community: iPS Core Facility; HSCI Therapeutic Screening Center; HSCI Center for Stem Cell Bioinformatics; Center for Human Cell Therapy (CHCT)/Trans Lab; Center for Human Antibody Therapeutics (CHAT); Humanized Neonatal Mouse Center (HNMC); as well as flow cytometry cores at Boston Children’s Hospital, Joslin Diabetes Center, Massachusetts General Hospital, and the Harvard University Department of Stem Cell and Regenerative Biology. Additionally, members of the HSCI research community have access to the production of clinical-grade cellular therapy products through the Connell O’Reilly Cell Manipulation Core Facility (DF/HCC) at DFCI directed by Jerome Ritz, MD, HSCI Executive Committee and Principal Faculty member.
The Hoggatt Laboratory is a stem cell and regenerative biology research group at Harvard Medical School / Massachusetts General Hospital and is affiliated with both the MGH Cancer Center and Center for Transplantation Sciences as well as the Harvard Stem Cell Institute. We are broadly interested in tissue regeneration and stem cell biology, with a particular focus on translational research to enhance bone marrow transplantation.
Research efforts over the last several decades working to develop therapies have largely focused on finding “magic bullets”, a small molecule or perhaps protein biologic that can be given to the patient as a drug to cure their disease. We believe that the cures of the future will come from tapping in to the body’s natural regenerative capacities or will use cellular therapies, namely stem cell transplantation. Our goals are to discover new regenerative pathways within the body to allow for disease correction and to make stem cell transplantation faster, safer, cheaper and better to broaden its use to more patients.
An autologous stem cell transplant (ASCT) is a procedure in which high-dose chemotherapy is used to treat certain cancers. The procedure was formerly known as a bone marrow transplant. However, as hematopoietic (blood-forming) stem cells from the blood are now used, the procedure is referred to as a peripheral blood stem cell transplant.
A stem cell transplant “rescues” your body with an infusion of healthy blood-forming cells following high dose chemotherapy. The infused stem cells migrate to the bone marrow where they produce blood cells that your body and immune system require.
We offer a patient-centered approach that is comprehensive and caring. Our goal is to provide our patients and their families mental, physical and emotional support during a very stressful time. During the hospitalization, a number of doctors participate in the care of transplant patients. Lahey Hospital & Medical Center is a teaching hospital, and inpatients may be seen by physicians-in-training (interns, residents, and fellows) and medical students. In all cases, however, their involvement will be supervised by a physician on the staff of Lahey Hospital & Medical Center.
RESEARCH AT MASS GENERAL
Discover the largest hospital-based research program in the U.S. and how clinicians and scientists chart new terrain in biomedical research to treat and prevent human disease and bring the latest advances to patient care
David T. Scadden, M.D.
Gerald and Darlene Jordan Professor of Medicine, Harvard University
Director, Center for Regenerative Medicine, Massachusetts General Hospital
Co-Director, Harvard Stem Cell Institute, Harvard University
Co-Chair, Department of Stem Cell and Regenerative Biology, Harvard University
Chief, Hematologic Malignancies, MGH Cancer Center
Dr. Scadden’s laboratory is focused on hematopoietic stem cell biology. We are trying to solve three problems that limit the ability of stem cells to be used more effectively as therapy. The first is stem cell number. We are using a range of genetic and cell biologic approaches to understand the cell-autonomous and extrinsic regulators of stem cell cycling and self-renewal. Specifically, our group uses both comparative genomics and shRNA forward screening to identify candidate mediators of the self-renewal program in hematopoietic stem cells. Second, we are studying stem cell localization as delivery of stem cells to specific sites is critical for their application clinically. We have identified novel mechanisms regulating the ability of the stem cell to engage its proper niche using genetic models and high resolution in vivo imaging. Third, we are deeply interested in viewing the stem cell through the microenvironment in which it resides. We have defined key elements of the stem cell niche in the bone marrow and how these features may be modified to improve stem cell number and function. We are now applying these to in vitro models adaptable to high throughput chemical and genetic analyses to further understand niche-stem cell interactions and how they might be modified therapeutically.
Microbot Medical Inc., a pre-clinical medical device company, researches, designs, and develops micro-robotics assisted medical technologies targeting the minimally invasive surgery space. The company, through its ViRob and TipCAT micro-robotic technologies, is developing two product candidates, including the Self Cleaning Shunt for the treatment of hydrocephalus and normal pressure hydrocephalus; and a self-propelling, semi-disposable endoscope, which is used in colonoscopy procedures. It also holds an intellectual property portfolio that comprises 9 patent families, which include 9 patents granted in the United States, 12 patents granted outside the United States, and 15 patent applications pending worldwide. Microbot Medical Inc. was founded in 2010 and is based in Hingham, Massachusetts.
WHAT WE DO
All around the world, researchers trying to develop cures and treatments for life’s significant medical conditions were looking for a reliable and timely source of human-derived samples. StemExpress was founded in 2010 to meet that need and shorten the time it takes new treatment technologies to reach patients.
At researcher request, StemExpress collects human blood and tissue and isolates cells using specialized protocols and cutting-edge lab technology. Our Stem Cell Collection Centers welcome community members willing to make a difference by donating blood or bone marrow to science.
All of our donors receive a gift card for ranging from $25 to $350.
Scientists around the world are racing to unlock cures for diseases like diabetes and
heart disease. And you can help. Your donation can provide the blood and stem cells
scientists need for their research.
Researchers using stem cells in their work are getting ever closer to exciting cures. One project nearing its final phase of testing is a cure for sickle cell disease. Scientists would remove bone marrow from a patient, fix the genetic defect in the stem cells, and reintroduce those cells to the patient to create a healthy blood system.
Provia Laboratories, LLC is a consumer healthcare services company headquartered in Littleton MA, just outside Boston.
Provia Laboratories, LLC offers Store-A-Tooth™, the industry-leading dental stem cell banking service for preserving the stem cells found in baby teeth and wisdom teeth.
Store-A-Tooth has been available since 2006 from dentists across the U.S. At the core of our tooth transport device is the Save-A-Tooth® device, which is FDA-approved and ADA accepted for the preservation of avulsed teeth. We use Save-A-Tooth for tooth collection and transport to ensure optimal viability of your sample for processing and cryopreservation. Our laboratory is FDA-registered, CLIA-certified, and AABB-accredited.
As the research community learns more and more about stem cells and dental stem cells specifically, our goal at Provia Labs is to make this information available to you so that you can make the most informed decisions possible. We welcome questions and feedback – it helps us provide better information and services.
MISSION & VISION
Provia Labs’ mission is to set the standard in dental stem cell banking by providing the most scientifically-rigorous service and the best experience for our clients and dentist partners.
Our vision is to allow every person or family to have their own stem cells available as regenerative dentistry and medicine becomes routine.
Our guiding principles are to operate with integrity, to help people, to provide a service we would buy for our kids and family, and to advance the science of stem cells.