Functional, Regenerative, & Aesthetic Medicine located in Tacoma, WA
Medical Aesthetics offers regenerative and functional medicine services, as well as transformative aesthetic treatments, to patients in Tacoma, Washington.
Led by Dr. Barbara Mack and licensed esthetician Elina Miranda, the center specializes in the use of stem cells to naturally heal a wide range of conditions with no downtime and minimal discomfort. From injury recovery and weight loss to treatments for arthritis or aging skin, men and women can restore youth, function, and vitality to their bodies with the most innovative therapies available today.
As a certified provider of the ALMI™ procedure, Medical Aesthetics uses this unique treatment method to restore elasticity and supple texture to the skin, using stem cells harvested from the patient’s fatty tissue.
With a wide variety of gentle, minimally invasive procedures, patients can achieve everything from pain relief and improved mobility to sculpted thighs and full-body detoxification. With an emphasis on natural solutions, the team at Medical Aesthetics believes that each patient can look and feel their best without the need for surgical procedures.
Whether a patient has a chronic disease or an acute problem, Medical Aesthetics can deliver fast, safe, and effective solutions for the best possible results.
Our Mission at NatureWorks Acupuncture is to utilize the therapeutic effects of Chinese Medicine to strengthen your abilities to achieve a natural healing process. Modern research shows that Chinese Herbs and Acupuncture have powerful effects on many medical conditions. The combination of Acupuncture, Chinese herbs, Tui Na medical massage, Qi Gong, Nutrition and now Natural Stem Cell Therapy deliver a comprehensive approach to the health of the WHOLE BODY.
Chinese Medicine Diagnostics and Modern Science
We recognize that you are individual and that you need an individual approach to achieve your best health. Chinese Medical Pulse and Tongue diagnosis (among a multitude of other techniques) offer a true understanding of the root of your health problems. Rather than treating your symptoms, we can achieve a long-lasting change in your physical and mental constitution by recognizing the basis of the problem and balancing your individual metabolic homeostasis. Chinese Medicine could be summarized by this statement: “Only through the balance of YIN and YANG can you achieve the absence of disease.” Modern Research Science is currently merging with this brilliant ancient insight. Be part of the NEW MEDICINE that seeks a real cure! NOW AVOID TOTAL KNEE REPLACEMENT with natural stem cell therapy. Use the power of a natural regenerative Medicine!
We are located at the beautiful Liberty Bay Marina in Poulsbo, Washington. Come and relax at one of the most scenic waterfront sites in the Northwest. Our clinic is newly remodeled and every treatment room has a view of the water. Take 5 minutes out of your busy life and enjoy a stroll on the beach at the marina and waterfront park on your visit. Let the beach sunshine rejuvenate your Yang in the most powerful way nature intended.
No need to have a fear of needles! Acupuncture needles are as thin as a human hair and have nothing in common with hypodermic needles. They are coated for pain-free insertion. The purpose of Acupuncture is the activation of the parasympathetic nervous system and therefore is very relaxing. CHOOSE YOUR OWN MUSIC and feel all the pressure and worries fall away. We offer a multitude of Acupuncture styles including Chinese and Japanese styles that are individualized for your needs. Only at NatureWorks Acupuncture, you can experience the combination of Acupuncture, Massage, Herbs, Scientific Nutritional Advice and Qi Gong exercises. Come as you are and leave changed!
WHAT IS STEM CELL THERAPY?
The NeiJing says, “If the Sea of Marrow is abundant, vitality is good, the body feels light and agile, and the span of life will belong.” The sea of marrow is the home for important stem cells in your body!
Stem-cell therapy is becoming the treatment option of choice for the regeneration of organs. Regenerative medicine is a field of medical research developing treatments to repair or re-grow specific tissue in the body. There is a rising body of studies that reveals the power of mesenchymal stem cells. Stem cells are multipotent stromal cells that can differentiate into a variety of cell types,  including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). This phenomenon has been documented in specific cells and tissues in living animals and their counterparts growing in laboratory tissue culture. Most Human Tissue has a rapid turnover rate. It is the availability of stem cells that assists in this process. However, with advanced age, stem cells also age and proliferate much slower.
The aging of stem cells: Healing a skin injury in a baby can be observed within approximately one to two days. In adults over the age of 40 the same process can take weeks or even months. That is why we need to re-introduce new stem cells to rejuvenate the healing process in older adults.
Regenerative Medicine at Its Best- How does it work?
Stem-cells can be derived from the body’s own bone marrow and adipose tissue and if available from the umbilical cord. However recently cells derived from Amniotic and Umbilical cord source have shown to be the most effective, reliable, safe and least invasive. Up to 40% of birth are performed by C-section (1). As more and more Mothers choose to bank their umbilical cord, access to live stem-cells is becoming routine.
Once these concentrated cells are redeployed, the body’s own innate wisdom takes over. Signaled by inflammation, stem cells home in on damaged tissues, where they produce growth factors and other compounds necessary for repair and regeneration.
Some of them, such as vascular endothelial growth factors and angiogenesis mediators, stimulate the production of new blood vessels to restore circulation and oxygen supply. Others prevent apoptosis (programmed cell death) or boost the formation of various cell types. Another stem cell benefit is that they curb excessive inflammation and help regulate the immune response, which is key to the therapy’s benefits for inflammatory conditions and autoimmune diseases.
Proliance Surgeons is one of the largest surgical practices in the country, with over 425 providers including over 250 board-certified physicians providing treatment at more than 100 care centers in Washington State. Our range of specialties includes orthopedics, sports medicine, spine, ear nose & throat, general surgery, ophthalmology, obstetrics & gynecology, urology and more. Many of our surgeries are performed at our own outpatient surgery centers—where costs are often lower and recovery times faster than at a hospital. Patients return home the day of their surgery to begin healing and rehabilitation and get back to doing what they love, faster. Proliance physicians helped more than 650,000 patients last year alone and performed over 85,000 surgeries.
To be the leader in physician-managed healthcare services
Excellent surgical and clinical care for every patient, every day
Employee oriented | Physician driven | Community integrated
Integrity | Leadership | Loyalty | Mutual Respect | Innovation
Our values transcend all of our relationships:
patients, employees, physicians, colleagues, business associates
Meet Dr. Mark D. Wagner, MD, FAAFP
SPORTS MEDICINE | FAMILY PRACTICE | REGENERATIVE MEDICINE
Dr. Wagner provides compassionate, careful, and comprehensive attention to those seeking primary care for themselves and their family members. This is accomplished while remaining on the leading edge of Sports and Regenerative Medicine, offering contemporary and advanced nonsurgical technologies for musculoskeletal injuries and illness. These include PRP injections and stem cell therapies for conditions such as tendonitis and osteoarthritis.
As one of the most trusted and well-respected physicians in the Seattle area, Dr. Wagner makes a special effort to provide not only diagnosis and personalized treatment for each one of his patients but also takes the time to educate every patient on all treatment options.
He believes that every patient should have the knowledge to take an active role in making the best decisions for his or her own health.
A new and exciting advancement in orthopedics…”
Dr. Wagner is, without question, the leader in the field of Regenerative Medicine, here in the Pacific Northwest.
Stem cell therapy and Platelet Rich Plasma (PRP) injections are both offered to alleviate pain and repair injury in the body’s tendons and joints, proving to be very effective in such conditions as osteoarthritis, tendon injuries and meniscus and labrum tears.
Each year, Dr. Wagner provides stem cell procedures and PRP injections for hundreds of his patients, witnessing the outstanding results first-hand.
Stem cell therapy: new era in orthopedic medicine.
Dr. Wagner is, without question, the leader in the field of Regenerative Medicine, here in the Northwest. Each Year, Dr. Wagner provides stem cell procedures and PRP injections for hundreds of his patients, for conditions such as osteoarthritis and various tendon injuries, witnessing the outstanding results first-hand. At Seattle Sports & Regenerative Medicine, Dr. Wagner performs both PRP (Platelet Rich Plasma) and Stem Cell Therapies. By using only stem cells from the patient’s own body, the patient receives the safest and most effective treatment, dramatically decreasing any chance of adverse effects. This is often referred to as “autologous,” meaning cells or tissue removed from the same individual that is receiving the treatment.
Meet Dr. Tami Meraglia, Medical Director of The Seattle Stem Cell Center
Dr. Tami is a certified physician in Aesthetic Medicine and Integrative & Natural Medicine. She is the type of doctor that other doctors go to. Her unique combination of experience and expertise allows her to not only make her patients look great on the outside, but she is also uniquely qualified to treat patients using the newest and most cutting edge medical and nutritional therapies to heal and retard the effects of hard living, illness, and age.
Many physicians treat symptoms, Dr. Tami discovers and treats root causes. What that means for you is a real diagnosis and a program personally tailored for you by one of the top doctors in the country. Despite her high level of training and accolades, her approach is holistic and cutting edge. She is committed to increasing the quality of life for all of her patients. She cares about each of her patients and treats them like family.
Additionally, Dr. Tami is on the faculty of the American Academy of Aesthetic Medicine, and lectures around the world on Aesthetics and Bio-identical hormones for men and women as well as the benefits of stem cell therapy. She is featured as the Health and Beauty Expert for King 5 Health Link regularly has been the health expert for articles for Shape magazine and has hosted two radio shows about Aesthetic Medicine and cutting edge natural medicine and a best selling author.
THREE THINGS YOU SHOULD KNOW
BEFORE YOU DO YOUR STEM CELL
TREATMENT ANYWHERE BUT SEATTLE.
Member of Clinical Trial
Medical Director Dr. Tami is a member of the US-based Clinical Trial.
Three Stem Cell Treatments
The Seattle Stem Cell Center is the ONLY treatment center that gives you THREE STEM CELL TREATMENTS for LESS than the cost for two treatments.
Lastly, Dr Tami is a physician that is specialized in aesthetic medicine and stem cell medicine. You will receive the most scientifically advanced Stem Treatment in America today, AND the most effective holistic follow-up treatment for nutrition health optimization.
Swedish Center for Blood Disorders and Stem Cell Transplantation
The Swedish Cancer Institute focuses on treating all blood-related diseases at the Center for Blood Disorders and Stem Cell Transplantation.
Our team of renowned specialists offers cutting-edge therapies, including novel immunotherapies and stem cell transplantation, while providing access to a wide range of clinical trials. The center is active in the institute’s personalized medicine program, using gene sequencing of the patient’s unique tumor to understand which treatment would be best for each individual patient.
Leukemia (acute and chronic)
Lymphoma (Hodgkin and non-Hodgkin)
Benign hematologic conditions
Stem Cell Transplant
Stem cells are immature cells found in the bone marrow that “grow up” to be blood cells. There are three types of blood cells: white blood cells, which fight infection; red blood cells, which carry oxygen to and remove waste products from organs and tissues; and platelets, which enable the blood to clot. In a stem-cell transplant, cells are taken from a patient’s bone marrow or peripheral blood, cleansed of any cancer cells and frozen until they are ready to be used.
Stem Cell Pre-Collection and Mobilization
The first step in the stem cell transplant process is referred to as pre-collection. During this time, patients undergo mobilization. In this video, Dr. Pagel, medical oncologist, answers some frequently asked questions about the pre-collection process.
Stem Cell Collection
After mobilization, a patient’s care team will decide when a patient is ready to begin the next step in the stem cell transplant process, known as collection. In this video, Dr. Pagel, medical oncologist, answers some frequently asked questions about the collection process.
Stem Cell Transplant
The final step of the stem cell transplant is the transplant itself. Stem cells that were previously mobilized and then collected will be returned to the patient’s body. In this video, Dr. Pagel, medical oncologist, answers some frequently asked questions about the transplant process.
Medical oncologists are physicians who specialize in treating cancer with a variety of cancer-fighting medications. Our medical oncologists meet with patients and their families to determine an individualized treatment plan working with other cancer specialists and oncology nurses.
If your doctor believes you are a good candidate to participate in a clinical trial evaluating a new treatment or more effective combinations of treatments — and you agree — you will have access to the very latest in research treatments.
What Cancer Types Can Be Treated With a Stem Cell Transplant?
For a few types of cancer including leukemia, lymphoma – Hodgkins and non-Hodgkins and multiple myeloma, stem-cell transplantation may be effective.
Risks & Side Effects
Patients who undergo a stem-cell procedure may experience short-term side effects such as nausea, vomiting, fatigue, loss of appetite, mouth sores, hair loss, and skin reactions. Additionally, these patients are at high risk of infection during the seven to ten days that their blood counts are low.
Coordination of Insurance Benefits
Stem-cell transplant procedures are very expensive. Many health insurance companies cover some of the costs of transplantation for certain types of cancer. Insurers may also cover a portion of the costs if special care is required when the patient returns home. Federal government programs and local service organizations may also be able to help.
Editing the genome without breaking it.
Universal Cells use recombinant adeno-associated virus (rAAV)-mediated gene editing to efficiently edit chromosomal genes without the use of genotoxic nucleases. rAAV vectors are effective and safe and have been used in numerous clinical trials. We have licensed a stem cell-tropic rAAV vector serotype for engineering human pluripotent stem cells. Our technology allows us to produce customized stem cells that contain deletions, insertions, or point mutations at any genomic position.
Unlike nuclease-based genome editing, our approach is not genotoxic. It does not require a double-strand break, generate off-target alterations to the genome, or produce unwanted mutations at the target site. It also does not introduce nuclease genes into the cell that may have unintended effects.
A major advantage of universal donor cells is that a single cell line can be differentiated into a therapeutic cell type, tested for regulatory approval, and used in multiple recipients, creating an off-the-shelf product. We can provide our engineered stem cells, or our gene-editing technology can be applied to a stem cell line of choice to create customized donor cells.
Universal Cells addresses the allogeneic rejection problem by manipulating human leukocyte antigen (HLA) expression in human stem cells. Multiple HLA class I and class II proteins must be matched for histocompatibility in allogeneic recipients. We eliminate the expression of these polymorphic HLA proteins by gene editing, express specific non-polymorphic HLA molecules in order to provide essential class I signals that block lysis by Natural Killer cells, and introduce suicide genes for enhanced safety.
Significant evidence supports the concept that these HLA-engineered cells will function normally and avoid allogeneic rejection after transplantation.
1) Rare individuals who are HLA class I-negative or HLA class II-negative are relatively healthy, demonstrating that HLA-negative human cells can form all essential organs.
2) Mice lacking major histocompatibility complex (MHC) class I and class II antigens (the murine equivalent of HLA) have been extensively studied and are healthy except for a lack of CD4+ and CD8+ T cells. Importantly, transplantation experiments have shown that organs or cells from class I-negative mouse donors survive longer in allogeneic recipients (sometimes persisting indefinitely), including liver cells, kidneys, hearts, and pancreatic islets. These mouse experiments suggest that HLA-engineered human cells will also survive longer than allogeneic cells in many of the clinical settings being considered for pluripotent stem cells.
HLA class I engineering
HLA-A, B and C are polymorphic class I proteins expressed by most nucleated cells that must be matched for histocompatibility. The Beta-2 Microglobulin (B2M) gene encodes a common subunit essential for cell surface expression of all HLA class I heterodimers (the other subunits are the heavy chains for HLA-A, B, C, E, F, or G), so B2M-/- cells are class I-deficient. We edit both B2M genes to create human pluripotent cells that lack polymorphic class I proteins. These editing steps also introduce a Thymidine Kinase (TK) suicide gene to allow for in vivo elimination of transplanted cells.
For some cell types, a lack of class I expression leads to lysis by Natural Killer (NK) cells. To overcome this “missing self” response, we simultaneously knock in the heavy chain of the non-polymorphic HLA-E gene using HLA single-chain technology (see below). This provides a class I-positive signal to inhibit NK cells. These class I-engineered stem cells can serve as universal donor cells in applications where the differentiated cell product does not express HLA class II.
HLA class II engineering
Unlike HLA class I, class II proteins lack a common subunit that can be edited to prevent surface expression. Therefore our approach is to edit both copies of the RFXANK transcription factor gene required for class II expression. Patients with RFXANK mutations do not express HLA class II molecules on their antigen-presenting cells. Combining class I and class II engineering create a universal donor stem cell line appropriate for deriving any differentiated cell product.
If desired, specific HLA class II alpha and beta chain transgenes can be expressed in RFXANK-/-cells from a RFXANK-independent promoter.