Personalized Stem Cell Treatment May Relieve Multiple Sclerosis Symptoms
Stem cell therapy shows tremendous promise in treating many illnesses and diseases. One disease which stem cell research has focused on is multiple sclerosis. A recent British study done on mice suggests that personalized stem cell treatment may relieve MS symptoms in humans.
Study Touts Promise of Personalized Stem Cell Therapy
Led by researchers at the University of Cambridge in England, the study used mice that had been manipulated to develop MS. With these mice, researchers transplanted neural stem cells directly into the mice’s cerebrospinal fluid reducing the amount of succinate found in the fluid. Succinate is a metabolite that sends signals to macrophages and microglia. This metabolite tricks the cells into causing inflammation in cerebrospinal fluid, but not in the blood.
Researchers injected neural stem cells directly into the cerebrospinal fluid. Macrophages and microglia–the immune cells that were causing the inflammation due to the succinate–became ‘reprogrammed’. As a result, it lead to a decrease in inflammation and secondary damage to both the brain and spinal cord.
A Promising Result
Researchers are optimistic regarding the results of the study. Dr Stefano Pluchino, a research scientist from the Department of Clinical Neurosciences at the University of Cambridge and lead author of the study, stated the following:
Our mouse study suggests that using a patient’s reprogrammed cells could provide a route to personalised treatment of chronic inflammatory diseases, including progressive forms of MS…This is particularly promising as these cells should be more readily obtainable than conventional neural stem cells and would not carry the risk of an adverse immune response.
This sentiment was echoed by Dr Luca Peruzzotti-Jametti, the first author of the study and a training fellow with Wellcome Trust Research who co-funded the study:
We made this discovery by bringing together researchers from diverse fields including regenerative medicine, cancer, mitochondrial biology, inflammation and stroke and cellular reprogramming. Without this multidisciplinary collaboration, many of these insights would not have been possible.
The Healing Power of Stem Cells
Over the past two decades, there has been increased research regarding the healing properties of stem cells. Stem cells provide the very foundation for human formation. Over different periods of your life cycle, different stem cell types are formed to help the body repair and heal itself.
Stem cells have two unique properties; they are able to self-renew and have the ability to self-differentiate or develop into specialized cells depending on body type. Personalized stem cell therapy involves the introduction of healthy stem cells into an area of the body affected by illness or disease. The influx of stem cells in those areas help rejuvenate itself by promoting healing.
In the simplest terms, personalized stem cell therapies begin by extracting cells from the body’s fat stores. Once these cells are separated from fat cells by means of centrifuge, they are administered in body areas by a mixture known as PRP or platelet-rich plasma.
New Stem Cell Therapies for MS On the Horizon?
In addition to the Cambridge study, there are other personalized stem cell therapies for MS that are under current research. One example is hematopoietic stem cell transplantation (HCBT). The concept behind HCBT is that it attempts to restart the immune system which is responsible for damaging both the brain and spinal cord in multiple sclerosis. With this therapy, stem cells are taken from their bone marrow or blood and are reintroduced to the body after a person’s existing immune system is depleted through chemotherapy.
According to information from the National MS Society, the process for this therapy is as follows:
- Patients are administered some form of chemotherapy for up to 10 days to stimulate the production of bone marrow stem cells and promote their release into the blood. Then some blood is drawn from a vein and the stem cells in the blood are stored for later use.
- Then the individual is usually hospitalized, and given a powerful mix of chemotherapies for up to 11 days to kill or suppress immune cells throughout the body.
- The stored stem cells are then infused into the bloodstream through a vein.
- The individual is usually given medicines such as antibiotics to help combat infection
- The person remains in the hospital for an additional period of time while the immune system begins to rebuild itself. Sometimes individuals are discharged from the hospital in two to four weeks, but this can be longer.
- The immune system gradually rebuilds itself within 3 to 6 months.
According to the organization, HCBT is considered experimental and is not approved by the Food and Drug Adminstration (FDA).
Do You Have Further Questions About Personalized Stem Cell Therapy?
If you are looking for further information about stem cell therapy, call the professionals at Stem Cell Authority today. We have the resources you need in order to become more aware of this emerging therapy breakthrough. If you are looking for stem cell treatment, our team can find the facilities that provide treatments to fit your unique needs.
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